Primary paediatric TH1 immunodeficiency with BCGosis
نویسندگان
چکیده
Introduction: In tuberculosis (TB) endemic regions BCG vaccine is administered at birth in an effort to protect against neonatal tuberculous meningitis. However, this live vaccine facilitates overwhelming systemic infections by otherwise innocuous organisms in infants with cellular primary immunodeficiencies . Case Report: Our case is a seven month old infant who developed abscess at BCG vaccination site followed by disseminated BCGosis and was diagnosed to have TH1 immunodeficiency. Conclusion: Dissemination following BCG vaccination warrants prompt investigation to diagnose primary immunodeficiency disorders in HIV seronegative individuals.
منابع مشابه
A Case of Probable MHC Class II Deficiency with Disseminated BCGitis
Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency disease characterized by abnormality of MHC class II molecules surface expression on peripheral blood lymphocytes and monocytes. Clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as SCID (severe combined immunodeficien...
متن کاملClinical Characteristics and Immunogenetics of BCGosis/BCGitis in Chinese Children: A 6 Year Follow-Up Study
In this study, the clinical and immunogenetical features in a cohort of Chinese patients with BCGosis/BCGitis were investigated. For the patients with abnormal immunological functions, Sanger sequencing was used to identify the involved genes. There were 74 confirmed cases of BCGosis/BCGitis during 2007-2012. Classified by infected tissues and organs, no cases only had local infection, 39 patie...
متن کاملA Review of Primary Immunodeficiency Diseases with Skin Manifestations
Introduction: Primary immunodeficiencies (PID) are rare heterogeneous disorders with defects in which one or more components of the immune system are malfunctioning. Clinical presentations of the patients according to type of immunodeficiency are variable. The majority of these patients are susceptible to infections depending on the type of disorder. In these patients, one of the most important...
متن کاملEvaluation of Clinical and Laboratory Data in Patients with Recurrent Infections and Suspected Immunodeficiency
Background: Frequent infections is among the most frequent clinical dilemmas for primary care physicians. Immunodeficiency disorders are a heterogeneous group of illnesses that predispose patients to the recurrent infections, autoimmunity and malignancies. The aim of this study was to evaluate the clinical and laboratory data collected for the final diagnosis of patients referred with recurrent...
متن کاملPrimary Hepatic Burkitt’s Lymphoma in a Patient With Acquired Immunodeficiency Syndrome
Primary non-Hodgkin lymphoma of liver is a very rare malignancy. Here we report a case of primary hepatic Burkitt’s lymphoma in a 34-year old man who was known case of acquired immunodeficiency syndrome (AIDS) and presented with weight loss, abdominal pain, and fever. Positive laboratory findings were mild anemia and elevated levels of lactate dehydrogenase (LDH) and alkaline phosphatase (AL...
متن کامل